What is the primary location of lesions in atopic dermatitis?

Atopic dermatitis primarily manifests lesions on flexor surfaces, which include areas such as the inner elbows, behind the knees, and around the neck. This pattern is particularly characteristic of the condition, reflecting the underlying pathophysiological mechanisms related to skin barrier dysfunction and immune response.

In infants, for instance, lesions may also appear on the face and scalp, but as individuals age, the typical location shifts to the flexor surfaces. This shift aligns with the chronic nature of atopic dermatitis, which often becomes more pronounced in these areas due to factors such as friction, moisture, and skin folding that can exacerbate inflammation and irritation.

While other choices mention areas where lesions can occur, they are not the hallmark locations associated with atopic dermatitis in the majority of cases, particularly in older children and adults. The understanding of these preferred sites helps healthcare providers diagnose and manage the condition effectively.