What is NOT typically a sign of cholecystitis?

Cholecystitis, which is the inflammation of the gallbladder, is characterized by several clinical signs that indicate an inflammatory process. These typically include fever, suggesting a systemic response to infection or inflammation, and leukocytosis, which is an elevated white blood cell count that occurs as the body responds to the inflammatory process. Additionally, a positive Murphy's sign, which is elicited during physical examination when a patient experiences pain upon deep palpation of the right upper quadrant while inhaling, is also commonly associated with cholecystitis.

Marked weight gain is not a typical sign of cholecystitis because this condition often leads to symptoms such as abdominal pain, nausea, and vomiting, which can result in reduced appetite and subsequent weight loss rather than an increase. Therefore, among the options presented, marked weight gain is the one that does not fit the clinical picture associated with cholecystitis.