What is a primary risk factor for the development of actinic keratoses, which can lead to skin cancer?

The primary risk factor for the development of actinic keratoses is sun exposure. Actinic keratoses are precancerous lesions that occur due to prolonged exposure to ultraviolet (UV) radiation from the sun. Over time, this radiation damages the DNA in skin cells, leading to changes that manifest as rough, scaly patches on sun-exposed areas of the skin. These lesions are considered a warning sign and are associated with an increased risk of developing skin cancer, particularly squamous cell carcinoma.

While excessive alcohol consumption, genetic predisposition, and the use of certain medications may contribute to skin health issues or influence cancer risk, they are not primary risk factors for actinic keratoses specifically. Sun exposure directly correlates with the etiology of these lesions, making it the most significant factor in their development. Understanding the role of UV radiation in skin pathology highlights the importance of protective measures like sunscreen and limiting sun exposure to reduce the incidence of actinic keratoses and subsequent skin cancers.