In overdose cases, which substance is associated with niacin?

Niacin, also known as vitamin B3, can cause significant flushing and other symptoms when taken in high doses, particularly in the context of overdose. Aspirin is often recommended as a preventive measure to alleviate the flushing effect caused by niacin. The mechanism is thought to involve aspirin's ability to inhibit prostaglandin synthesis, which plays a role in the flushing response.

In cases where individuals take large amounts of niacin, aspirin can help mitigate some of the uncomfortable side effects associated with higher doses. This relationship highlights the role of aspirin not just as a pain reliever or anti-inflammatory, but also in managing specific side effects of niacin supplementation.

The other substances listed do not share the same connection with niacin overdose. Heparin is an anticoagulant that is unrelated to niacin. Activated antithrombin is a form of treatment associated with specific clotting disorders and is not involved with niacin. Fish oil, while it may have its own set of side effects or interactions, does not relate directly to managing the effects of niacin overdose. Therefore, aspirin stands out as the substance commonly associated with mitigating niacin overdose symptoms.